These podcasts are my favorite sources of audio content related directly or semi-directly to what I do every day in the office -- innovation, ideas, management, perspective, etc.
The HBR IdeaCastThis is from the Harvard Business Review -- each episode is generally composed of an interview with an author or researcher about a particular set of ideas or advice about management and business, as well as a short "tips" segment toward the end.
Escape From Cubicle Nation Pamela Slim focuses on creating a work life that you're passionate about -- for many, this may mean starting your own business or otherwise leaving corporate culture. For me, however, the focus is on creating a work environment that is appealing to people and gives them space to grow inside a larger organization. In addition, I find her reflections on marketing, discovering your own strengths, and developing services to be extremely relevant in an academic IT environment. She has a great blog, too.
Startup Nation 